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SC-26196

SIGMA/PZ0176 - ≥98% (HPLC)

Synonym: SC-26196; a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; 2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile

Empirical Formula (Hill Notation): C27H29N5
Molecular Weight: 423.55
MDL Number: MFCD11226148
Linear Formula: C27H29N5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0176-5MG 5 mg
 $147.00
1/EA		 Add To Favorites
45-PZ0176-25MG 25 mg
 $437.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChI key QFYKXKMYVYOUNJ-JBASAIQMSA-N
manufacturer/tradename Pfizer®
originator Pfizer
Quality Level 100 
SMILES string N#CC(CCCN1CCN(CC1)N=Cc2cccnc2)(c3ccccc3)c4ccccc4
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Application: SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:
• in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component
• in hepatic HepG2 cells
• in glioblastoma cell lines to test its effect post-radiation treatments
Biochem/physiol Actions: SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.
Legal Information: Pfizer is a registered trademark of Pfizer, Inc.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.
Other Notes: This compound was developed by Pfizer for Lipid Signaling research . To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer .

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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