PD184352

SIGMA/PZ0181 - ≥98% (HPLC)

Synonym: 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide; CI-1040

CAS Number: 212631-79-3
Empirical Formula (Hill Notation): C₁₇H₁₄ClF₂IN₂O₂
Molecular Weight: 478.66
MDL Number: MFCD02683961
Linear Formula: C₁₇H₁₄ClF₂IN₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PZ0181-5MG	5 mg	$143.00 1/EA	Add To Favorites
45-PZ0181-25MG	25 mg	$568.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChI key	GFMMXOIFOQCCGU-UHFFFAOYSA-N
Quality Level	100
SMILES string	Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F
solubility	DMSO: ≥30 mg/mL
storage temp.	room temp

Biochem/physiol Actions:	PD184352 (CI-1040) is a highly selective MEK (MKK1; MAPK kinase) inhibitor.
Biochem/physiol Actions:	PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.
Features and Benefits:	This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	51111800

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