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PF-04457845

SIGMA/PZ0184 - ≥98% (HPLC)

Synonym: N-(3-pyridazinyl)-4-(3-[5-trifluoromethyl-2-pyridinyloxy]benzylidene)piperidine-1-carboxamide; N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide; PF-4457845

CAS Number: 1020315-31-4
Empirical Formula (Hill Notation): C23H20F3N5O2
Molecular Weight: 455.43
MDL Number: MFCD18782721
Linear Formula: C23H20F3N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0184-5MG 5 mg
 $128.00
1/EA		 Add To Favorites
45-PZ0184-25MG 25 mg
 $495.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)
InChI key BATCTBJIJJEPHM-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NC1=NN=CC=C1)N(CC2)CCC2=CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3
solubility DMSO: 20 mg/mL
storage temp. room temp
Biochem/physiol Actions: PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.
Biochem/physiol Actions: Potent irreversible FAAH inhibitor
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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