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PF-3644022 hydrate

SIGMA/PZ0188 - ≥98% (HPLC)

Synonym: (10R)-9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-f]quinolin-8-one hydrate

Empirical Formula (Hill Notation): C21H18N4OS · xH2O
Molecular Weight: 374.46 (anhydrous basis)
MDL Number: MFCD21363374
Linear Formula: C21H18N4OS · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0188-5MG 5 mg
 $162.00
1/EA		 Add To Favorites
45-PZ0188-25MG 25 mg
 $619.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts PZ0188-5MG.

 

assay ≥98% (HPLC)
color yellow to orange
form powder
InChI 1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1
InChI key WHVUIWUUCVXAGR-UTONKHPSSA-N
Quality Level 100 
SMILES string O.C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1
solubility DMSO: ≥15 mg/mL
storage temp. 2-8°C
Application: PF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS) and in colorectal carcinoma cells (CT26).
Biochem/physiol Actions: PF-3644022 hydrate is a MK2 inhibitor
Biochem/physiol Actions: PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC50 = 1.6 and 10.3 μM, respectively) and blocks TNFα production and paw swelling in a streptococcal cell wall-induced arthritis in rats.
Features and Benefits: This compound is featured on the MAPKAPs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes: PF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF3644022 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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