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Crizotinib

SIGMA/PZ0191 - ≥98% (HPLC)

Synonym: (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine; PF 2341066; PF-02341066; PF02341066; Xalkori

CAS Number: 877399-52-5
Empirical Formula (Hill Notation): C21H22Cl2FN5O
Molecular Weight: 450.34
MDL Number: MFCD12407409
Linear Formula: C21H22Cl2FN5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0191-5MG 5 mg
 $146.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChI key KTEIFNKAUNYNJU-GFCCVEGCSA-N
Quality Level 100 
SMILES string C[C@@H](Oc1cc(cnc1N)-c2cnn(c2)C3CCNCC3)c4c(Cl)ccc(F)c4Cl
storage temp. room temp
Application: Crizotinib has been used:
• to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis
• to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells
• to restore sensitivity to erlotinib
Biochem/physiol Actions: ATP-competitive c-MET / ALK Inhibitor
Biochem/physiol Actions: Crizotinib (PF-02341066) is an ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK). Crizotinib is a highly specific inhibitor of c-Met and ALK among > 120 different RTKs surveyed. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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