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Prinomastat hydrochloride

SIGMA/PZ0198 - ≥95% (HPLC)

Synonym: (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride; AG 3340 hydrochloride; AG-3340 hydrochloride; AG3340 hydrochloride

CAS Number: 192329-42-3 (free base)
Empirical Formula (Hill Notation): C18H21N3O5S2 · HCl
Molecular Weight: 459.97
Linear Formula: C18H21N3O5S2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0198-5MG 5 mg
 $141.00
1/EA		 Add To Favorites
45-PZ0198-25MG 25 mg
 $557.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
InChI key UQGWXXLNXBRNBU-NTISSMGPSA-N
Quality Level 100 
SMILES string Cl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
solubility H2O: 15 mg/mL (clear solution)
storage condition desiccated
storage temp. room temp
Application: Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells.
Biochem/physiol Actions: Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.
Biochem/physiol Actions: Prinomastat is a matrix metalloprotease (MMP) inhibitor.
General description: Prinomastat comprises hydroxamic acid group and chelates with zinc ion.
Packaging: 5, 25 mg in glass bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H360
Precautionary statements P201 - P308 + P313
Hazard Codes T
Risk Statements 60-61
Safety Statements 53-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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