PD 0332991 isethionate

SIGMA/PZ0199 - ≥98% (HPLC)

Synonym: 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1); Palbociclib isethionate

CAS Number: 827022-33-3
Empirical Formula (Hill Notation): C₂₄H₂₉N₇O₂ · C₂H₆O₄S
Molecular Weight: 573.66
MDL Number: MFCD22666589
Linear Formula: C₂₄H₂₉N₇O₂ · C₂H₆O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PZ0199-25MG	25 mg	DISCONTINUED

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)
InChI key	LYYVFHRFIJKPOV-UHFFFAOYSA-N
Quality Level	100
SMILES string	OCCS(O)(=O)=O.CC(=O)C1=C(C)c2cnc(Nc3ccc(cn3)N4CCNCC4)nc2N(C5CCCC5)C1=O
solubility	H₂O: 5 mg/mL, clear
storage temp.	room temp

Application:	PD 0332991 isethionate has been used: • to incubate MCF10A cells to verify cyclin D1 inhibition of autophagy involved cyclin-dependent kinase activity • as a cyclin dependent kinase 4 (CDK4) inhibitor to study its anticonvulsive property in Drosophila • to mimic the inhibitory effect of 5α-dihydrotestosterone (DHT) on HPr-1AR cell cycle progression and growth
Biochem/physiol Actions:	PD 0332991 is a potent selective inhibitor of CDK4 and CDK6.
Biochem/physiol Actions:	PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC₅₀ = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells.
Biochem/physiol Actions:	PD 0332991 might act as a chemsensitizer. It is useful in the treatment of breast cancer along with antioestrogens. PD 0332991 is also known to possess antitumor action.
Features and Benefits:	This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes:	PD0332991 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PD0332991 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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