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Sitaxentan sodium salt

SIGMA/PZ0203 - ≥98% (HPLC)

Synonym: N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide sodium salt; Sitaxsentan sodium salt; TBC-11251 sodium salt; Thelin

CAS Number: 210421-74-2
Empirical Formula (Hill Notation): C18H14ClN2NaO6S2
Molecular Weight: 476.89
Linear Formula: C18H14ClN2NaO6S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0203-5MG 5 mg
 $135.00
1/EA		 Add To Favorites
45-PZ0203-25MG 25 mg
 $541.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1
InChI key MDTNUYUCUYPIHE-UHFFFAOYSA-N
Quality Level 100 
SMILES string [Na+].Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)[N-]c4onc(C)c4Cl
solubility H2O: 10 mg/mL (clear solution)
storage temp. room temp
Biochem/physiol Actions: Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Biochem/physiol Actions: Sitaxentan is a potent and selective endothelin ET(A) receptor antagonist; antihypertensive.
Biochem/physiol Actions: Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR). Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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