Synonym: 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-ethanone; PF-4628935
CAS Number: 1383719-97-8
Empirical Formula (Hill Notation): C24H26ClN7OS
Molecular Weight: 496.03
Linear Formula: C24H26ClN7OS
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| manufacturer/tradename |
Pfizer® |
| originator |
Pfizer |
| Quality Level |
100  |
| solubility |
DMSO: 10 mg/mL, clear |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. Ghrelin and GSHR are involved in regulation of food intake and long-term energy homeostasis; GSHR ligands are of interest for obesity and other metabolic disorders. PF-04628935 is orally bioavailable and brain penetrant. |
| Legal Information: |
Pfizer is a registered trademark of Pfizer, Inc. |
| Legal Information: |
Sold for research purposes under agreement from Pfizer Inc. |
| Other Notes: |
This compound was developed by Pfizer for Cytokines & Growth Factors research . To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer .
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
