Synonym: (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride; PF-4859989 hydrochloride; PF04859989 hydrochloride
CAS Number: 177943-33-8
Empirical Formula (Hill Notation): C9H10N2O2 · HCl
Molecular Weight: 214.65
MDL Number: MFCD22419400
Linear Formula: C9H10N2O2 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1 |
| InChI key |
WZOBDOKCHIUXAY-FJXQXJEOSA-N |
| Quality Level |
100  |
| SMILES string |
N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl |
| solubility |
H2O: 20 mg/mL, clear |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-04859989 is a a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II). |
| Biochem/physiol Actions: |
PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates. |
| Features and Benefits: |
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
