Synonym: N-(5-{[2-Amino-7-(2-hydroxy-1 ,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl]carbonyl}pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide; N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide; PF 06273340; PF06273340
CAS Number: 1402438-74-7
Empirical Formula (Hill Notation): C23H22ClN7O3
Molecular Weight: 479.92
Linear Formula: C23H22ClN7O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
, white to yellow to brown |
| form |
powder |
| InChI |
1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) |
| InChI key |
BPIWZDNVMQQBQX-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC(CO)(C)N1C2=NC(N)=NC=C2C(C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=C1 |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. |
| Biochem/physiol Actions: |
PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
