PHA-408
SIGMA/PZ0266 - ≥98% (HPLC)
Synonym: 8-
CAS Number: 503555-55-3
Empirical Formula (Hill Notation): C29H27ClFN7O2
Molecular Weight: 560.02
Linear Formula: C29H27ClFN7O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| manufacturer/tradename | Pfizer® |
| originator | Pfizer |
| Quality Level | 100  |
| shipped in | dry ice |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | PHA-408 is a potent, selective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight binding, ATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular events, and to reduce inflammation in animal models of arthritis. |
| Legal Information: | Pfizer is a registered trademark of Pfizer, Inc. |
| Legal Information: | Sold for research purposes under agreement from Pfizer Inc. |
| Other Notes: | This compound was developed by Pfizer for Kinase Phosphatase Biology research . To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |