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PD168393

SIGMA/PZ0285 - ≥98% (HPLC)

Synonym: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide; PD 168393

CAS Number: 194423-15-9
Empirical Formula (Hill Notation): C17H13BrN4O
Molecular Weight: 369.22
MDL Number: MFCD02179207
Linear Formula: C17H13BrN4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0285-5MG 5 mg
 $111.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
InChI key HTUBKQUPEREOGA-UHFFFAOYSA-N
Quality Level 100 
SMILES string C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
solubility DMSO: 25 mg/mL, clear
storage temp. room temp
Application: PD168393 has been used in the acute inhibition of ErbB4.
Biochem/physiol Actions: PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
Biochem/physiol Actions: PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC50 value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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