Synonym: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide hydrobromide; Nirogacestat; PF 03084014 hydrobromide; PF 3084014 hydrobromide; PF-3084014 hydrobromide
CAS Number: 1290543-63-3 (free base)
Empirical Formula (Hill Notation): C27H41F2N5O · xHBr
Molecular Weight: 489.64 (free base basis)
Linear Formula: C27H41F2N5O · xHBr
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C27H41F2N5O.CH4/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4;/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35);1H4/t20-,23-;/m0./s1 |
| InChI key |
GLEYBLZDOTUZJH-WCRWPNQISA-N |
| Quality Level |
100  |
| SMILES string |
FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.C |
| solubility |
H2O: 1 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-03084014 inhibits the Notch signalling pathway. It contributes totumor suppression in breast, pancreatic carcinoma, hepatocellular carcinoma and progressive desmoid tumors. PF-03084014 in combination with dexamethasone elicits antileukemic effects in T-cell acute lymphoblastic leukemias (T-ALL). |
| Biochem/physiol Actions: |
PF-03084014 is a highly potent γ-secretase inhibitor that reduces Aβ production in vitro. PF-03084014 does not show a paradoxical increase in plasma Aβ at low concentrations in both preclinical species and humans. |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
GHS07