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PF-06651600

SIGMA/PZ0316 - ≥98% (HPLC)

Synonym: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate; PF 06651600

CAS Number: 1792180-81-4 (free base)
Empirical Formula (Hill Notation): C15H19N5O · C3H4O4
Molecular Weight: 389.41
Linear Formula: C15H19N5O · C3H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0316-5MG 5 mg
 $125.00
1/EA		 Add To Favorites
45-PZ0316-25MG 25 mg
 $384.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H19N5O.C3H4O4/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;4-2(5)1-3(6)7/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);1H2,(H,4,5)(H,6,7)/t10-,11+;/m0./s1
InChI key QMPMPSGDPRHZCG-VZXYPILPSA-N
Quality Level 100 
SMILES string C[C@@H]1N(C(C=C)=O)C[C@H](NC2=NC=NC3=C2C=CN3)CC1.OC(CC(O)=O)=O
solubility H2O: 5 mg/mL, clear (warmed)
storage temp. room temp
Biochem/physiol Actions: PF-06651600 is a potent and selective JAK3 inhibitor.
Biochem/physiol Actions: PF-06651600 specifically targets the ATP (adenosine triphosphate)-binding domain of JAK3 (Janus kinase 3). Loss of function of JAK3 is associated with severe combined immunodeficiency syndrome.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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