Synonym: 2-Amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-propanamide (2R,3R)-2,3-dihydroxybutanedioate; CP 424391-18; CP-424391 tartrate
CAS Number: 193273-69-7
Empirical Formula (Hill Notation): C28H35N5O4 · C4H6O6
Molecular Weight: 655.70
MDL Number: MFCD25977748
Linear Formula: C28H35N5O4 · C4H6O6
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C28H35N5O4.C4H6O6/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20;5-1(3(7)8)2(6)4(9)10/h4-13,22H,14-19,29H2,1-3H3,(H,30,35);1-2,5-6H,(H,7,8)(H,9,10)/t22-,28-;1-,2-/m11/s1 |
| InChI key |
MJGRJCMGMFLOET-MYPSAZMDSA-N |
| Quality Level |
100  |
| SMILES string |
O=C1N(C)N=C2CCN(C([C@H](NC(C(C)(C)N)=O)COCC3=CC=CC=C3)=O)C[C@]21CC4=CC=CC=C4.OC([C@H](O)[C@@H](O)C(O)=O)=O |
| solubility |
H2O: 20 mg/mL, clear |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
Capromorelin tartrate is a potent ghrelin receptor agonist/growth hormone secretagogue (Ki = 7 nM). In rat pituitary cells, Capromorlelin incudes growth hormone (GH) secretion with an EC50 of 3 nM. Capromorelin also increases gastric motility and has been studied recently in patients with spinal cord injuries. |
| General description: |
Capromorelin tartrate has been used in human clinical trials as a treatment for frailty in elderly adults. |
| General description: |
Capromorelin tartrate is an agonist of GHSR1a (ghrelin) receptors. It possesses structural homology with pyrazolinone-piperidine dipeptides. |
| Packaging: |
5, 25 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
51111800 |
GHS07