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PF-4800567 hydrochloride

SIGMA/PZ0328 - ≥98% (HPLC)

Synonym: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride; PF 4800567

CAS Number: 1391052-28-0
Empirical Formula (Hill Notation): C17H18ClN5O2 · HCl
Molecular Weight: 396.27
Linear Formula: C17H18ClN5O2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0328-5MG 5 mg
 $119.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H18ClN5O2.ClH/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12;/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21);1H
InChI key QZXZQMUZEHTFHD-UHFFFAOYSA-N
Quality Level 100 
shipped in dry ice
SMILES string Clc1cc(ccc1)OCc2n[n](c4ncnc(c42)N)C3CCOCC3.Cl
solubility DMSO: 5 mg/mL, clear (warmed)
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.
Biochem/physiol Actions: PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.
Other Notes: PF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF-4800567 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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