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PF-06726304 acetate

SIGMA/PZ0346 - ≥98% (HPLC)

Synonym: 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate

CAS Number: 1616287-82-1 (free base)
Empirical Formula (Hill Notation): C22H21Cl2N3O3 · C2H4O2
Molecular Weight: 506.38
Linear Formula: C22H21Cl2N3O3 · C2H4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0346-5MG 5 mg
 $125.00
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assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string CC(O)=O.CC(ON=C1C)=C1C2=CC(Cl)=C(CCN(CC3=C(C)C=C(C)NC3=O)C4=O)C4=C2Cl
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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