Synonym: 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
CAS Number: 1616287-82-1 (free base)
Empirical Formula (Hill Notation): C22H21Cl2N3O3 · C2H4O2
Molecular Weight: 506.38
Linear Formula: C22H21Cl2N3O3 · C2H4O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| Quality Level |
100  |
| SMILES string |
CC(O)=O.CC(ON=C1C)=C1C2=CC(Cl)=C(CCN(CC3=C(C)C=C(C)NC3=O)C4=O)C4=C2Cl |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor. |
| Packaging: |
5 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
