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PF-2545920 hydrochloride

SIGMA/PZ0351 - ≥97% (HPLC)

Synonym: 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrochloride; MP-10 hydrochloride; PF-02545920 hydrochloride; PF-920 hydrochloride

CAS Number: 898562-94-2 (free base)
Empirical Formula (Hill Notation): C25H20N4O · HCl
Molecular Weight: 428.91
MDL Number: MFCD30489759
Linear Formula: C25H20N4O · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0351-5MG 5 mg
 $125.00
1/EA		 Add To Favorites
45-PZ0351-25MG 25 mg
 $511.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to brown
form powder
InChI 1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
InChI key AZEXWHKOMMASPA-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl
solubility DMSO: 20 mg/mL, clear
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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