Synonym: N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
CAS Number: 1632250-50-0
Empirical Formula (Hill Notation): C22H20ClN7O · xHCl
Molecular Weight: 433.89 (free base basis)
Linear Formula: C22H20ClN7O · xHCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1 |
| InChI key |
FDTXHWQFIXYHCL-QGZVFWFLSA-N |
| optical activity |
[α]/D -60 to -50°, c = 1 in methanol |
| SMILES string |
O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5 |
| solubility |
H2O: 2 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
41121800 |
