PF-06928215
SIGMA/PZ038 - ≥98% (HPLC)
Synonym: rel-
CAS Number: 2570808-90-9
Empirical Formula (Hill Notation): C20H20N4O4
Molecular Weight: 380.40
MDL Number: MFCD32644796
Linear Formula: C20H20N4O4
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts PZ038-25MG.
This image depicts PZ038-25MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | room temp |
| Application: | PF-06928215 has been used to study its inhibitory effects on cyclic GMP-AMP synthase (cGAS). |
| Biochem/physiol Actions: | PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 μM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |