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Quinalizarin

SIGMA/Q2763 - ≥95% (HPLC)

Synonym: 1,2,5,8-Tetrahydroxy-9,10-anthraquinone; 1,2,5,8-Tetrahydroxyanthraquinone; Alizarin Bordeaux BD; Alizarinbordeaux; Alizarine Bordeaux; Alizarine Bordeaux B; C.I. 58500; C.I. Mordant Violet 26; Khinalizarin; NSC 144046; NSC 4896; PHF 016

CAS Number: 81-61-8
Empirical Formula (Hill Notation): C14H8O6
Molecular Weight: 272.21
EC Number: 201-366-6
MDL Number: MFCD00001205
Linear Formula: C14H8O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Q2763-5MG 5 mg
 $139.00
1/EA		 Add To Favorites
45-Q2763-25MG 25 mg
 $588.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color red
form powder
InChI 1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
InChI key VBHKTXLEJZIDJF-UHFFFAOYSA-N
mp ≥300 °C
Quality Level 100 
SMILES string Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
storage temp. room temp
Application: Quinalizarin has been used:
• as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
• as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
• to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines
Biochem/physiol Actions: Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.
Biochem/physiol Actions: Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.
Biochem/physiol Actions: Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.
Packaging: 5, 25 mg in glass bottle
Purity ≥95% (HPLC)
mp ≥300 °C
Storage Temp. room temp
Colour Index Number 58500
UNSPSC 12171500

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