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Quinidine

SIGMA/Q3625 - anhydrous

CAS Number: 56-54-2
Empirical Formula (Hill Notation): C20H24N2O2
Molecular Weight: 324.42
EC Number: 200-279-0
MDL Number: MFCD00135581
Linear Formula: C20H24N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Q3625-5G 5 g
 $103.00
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45-Q3625-25G 25 g
 $414.00
1/EA		 Add To Favorites

 

grade anhydrous
impurities ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
InChI 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
InChI key LOUPRKONTZGTKE-LHHVKLHASA-N
mp 168-172 °C (lit.)
originator Bayer
Quality Level 200 
SMILES string COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1
Application: Quinidine has been used:
• as an inhibitor of cytochrome P450 enzyme isoform CYP2D6
• as a potassium (K+) channel blocker in microglia
• to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes
Biochem/physiol Actions: Class IA antiarrhythmic; potassium channel blocker.
Biochem/physiol Actions: Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker. It is a potential antagonist for α1-adrenoceptors and contributes to hypotension. It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan. Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 g in glass bottle
mp 168-172 °C (lit.)
UNSPSC 12352200

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