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Quetiapine hemifumarate salt

SIGMA/Q3638 - ≥98% (HPLC)

Synonym: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate; Quetiapine fumarate

CAS Number: 111974-72-2
Empirical Formula (Hill Notation): C21H25N3O2S · 0.5C4H4O4
Molecular Weight: 441.54
MDL Number: MFCD03423782
Linear Formula: C21H25N3O2S · 0.5C4H4O4
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-Q3638-10MG 10 mg
$102.00
1/EA
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45-Q3638-50MG 50 mg
$434.00
1/EA
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChI key ZTHJULTYCAQOIJ-WXXKFALUSA-N
originator AstraZeneca
Quality Level 100 
SMILES string OC(=O)C=CC(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68
solubility DMSO: >10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.
Biochem/physiol Actions: Quetiapine hemifumarate is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
Biochem/physiol Actions: Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
Biochem/physiol Actions: Quetiapine promotes oligodendrogenesis in vitro. It is used in treating depressive disorders.
Features and Benefits: This compound is featured on the Dopamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Quetiapine is a derivative of dibenzothiazepine compound and is also referred to as seroquel and clemastine.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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