Ropivacaine hydrochloride monohydrate

SIGMA/R0283 - ≥98% (HPLC)

Synonym: (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate; (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate; Naropin hydrochloride monohydrate

CAS Number: 132112-35-7
Empirical Formula (Hill Notation): C₁₇H₂₆N₂O · HCl · H₂O
Molecular Weight: 328.88
MDL Number: MFCD00946578
Linear Formula: C₁₇H₂₆N₂O · HCl · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-R0283-10MG	10 mg	$92.70 1/EA	Add To Favorites
45-R0283-50MG	50 mg	$369.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
InChI key	VSHFRHVKMYGBJL-CKUXDGONSA-N
optical activity	[α]/D -9 to -12, c = 1 in methanol
originator	AstraZeneca
Quality Level	100
SMILES string	O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C
solubility	H₂O: 5 mg/mL, clear
storage condition	desiccated
storage temp.	2-8°C

Application:	Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.
Biochem/physiol Actions:	Local anaesthetic with less cardiotoxicity than bupivacaine.
Biochem/physiol Actions:	Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.
Biochem/physiol Actions:	Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.
Features and Benefits:	This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352203

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