Synonym: (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate; (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate; Naropin hydrochloride monohydrate
CAS Number: 132112-35-7
Empirical Formula (Hill Notation): C17H26N2O · HCl · H2O
Molecular Weight: 328.88
MDL Number: MFCD00946578
Linear Formula: C17H26N2O · HCl · H2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1 |
| InChI key |
VSHFRHVKMYGBJL-CKUXDGONSA-N |
| optical activity |
[α]/D -9 to -12, c = 1 in methanol |
| originator |
AstraZeneca |
| Quality Level |
100  |
| SMILES string |
O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C |
| solubility |
H2O: 5 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Application: |
Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation. |
| Biochem/physiol Actions: |
Local anaesthetic with less cardiotoxicity than bupivacaine. |
| Biochem/physiol Actions: |
Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers. |
| Biochem/physiol Actions: |
Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain. |
| Features and Benefits: |
This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom. |
| Packaging: |
10, 50 mg in glass bottle |
| Symbol |
 GHS05 |
| Signal word |
Danger |
| Hazard statements |
H318 |
| Precautionary statements |
P280 - P305 + P351 + P338 |
| Hazard Codes |
Xi |
| Risk Statements |
41 |
| Safety Statements |
26-39 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352203 |
