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Ramatroban

SIGMA/R0531 - ≥98% (HPLC), solid

Synonym: (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid; BAY u3405

CAS Number: 116649-85-5
Empirical Formula (Hill Notation): C21H21FN2O4S
Molecular Weight: 416.47
MDL Number: MFCD00887606
Linear Formula: C21H21FN2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R0531-5MG 5 mg
 $213.00
1/EA		 Add To Favorites
45-R0531-25MG 25 mg
 $802.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
InChI key LDXDSHIEDAPSSA-OAHLLOKOSA-N
originator Bayer
Quality Level 100 
SMILES string OC(=O)CCn1c2CC[C@H](Cc2c3ccccc13)NS(=O)(=O)c4ccc(F)cc4
solubility DMSO: ≥40 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Biochem/physiol Actions: Ramatroban aids in the reduction of myocardial ischemia-reperfusion injury, lipopolysaccharide-induced shock, and vagal neuroeffector transmission in the tracheal smooth muscle of experimental models. In addition, it also suppresses allergen and IgE antibody-mediated skin and nasal reactions and eosinophilia in animal models with asthma.
Biochem/physiol Actions: Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor.
Biochem/physiol Actions: Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor. It is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. It is more potent at the DP2 receptor than the TP receptor by 4-5 fold. It is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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