Rifapentine

SIGMA/R0533

Synonym: 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin; Cyclopentylrifampicin; DL 473

CAS Number: 61379-65-5
Empirical Formula (Hill Notation): C₄₇H₆₄N₄O₁₂
Molecular Weight: 877.03
EC Number: 262-743-9
Linear Formula: C₄₇H₆₄N₄O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-R0533-25MG	25 mg	$431.00 1/EA	Add To Favorites
45-R0533-100MG	100 mg	$1370.00 1/EA	Add To Favorites

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This image depicts SKU: R0533-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
assay	≥93.5%
form	powder or crystals
InChI	1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23?/t24-,26+,27+,28+,33?,38-,39+,43+,47-/m0/s1
InChI key	WDZCUPBHRAEYDL-OABFQHKQSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	N5(CCN(CC5)C6CCCC6)N=Cc1c2c(c3c(c4c(c(c3O)C)O[C@](OC=CC([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](C=CC=C(/C(=O)N2)C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O
storage temp.	2-8°C

Application:	Rifapentine is an antibiotic clinically used to treat tuberculosis. It is used in tuberculosis research.
Biochem/physiol Actions:	Rifapentine is a semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacteria and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription. It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Biochem/physiol Actions:	Semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacterial and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription.
General description:	Chemical structure: macrolide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	25, 100 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P261 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93.5%
Storage Temp.	2-8°C
UNSPSC	51283603

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