RANK/Fc Chimera from mouse
SIGMA/R0775 - ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Synonym: Osteoclast differentiation receptor, ODFR; Receptor activator of NF-κB
MDL Number: MFCD03703131
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | 60 kDa |
| packaging | pkg of 1 mg |
| potency | 10.12 μg/mL EC50 |
| Quality Level | 200  |
| recombinant | expressed in NSO cells |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | O35305  |
| Analysis Note: | The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes. |
| Application: | RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF- |
| Biochem/physiol Actions: | TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |