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RG-239 hydrate

SIGMA/R0783

Synonym: (3)-3-Hydroxy-3-(2-propen-1-yl)-lup-20(29)-en-28-oic acid hydrate; (3R)-3-Allyl-3-hydroxylup-20(29)-en-28-oic acid hydrate; 18 dia 2

Empirical Formula (Hill Notation): C33H52O3 · xH2O
Molecular Weight: 496.76 (anhydrous basis)
MDL Number: MFCD17215967
Linear Formula: C33H52O3 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R0783-5MG 5 mg
 $162.00
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assay ≥98% (HPLC)
form solid
InChI 1S/C33H52O3.H2O/c1-9-14-33(36)20-17-29(6)24(28(33,4)5)13-15-31(8)25(29)11-10-23-26-22(21(2)3)12-16-32(26,27(34)35)19-18-30(23,31)7;/h9,22-26,36H,1-2,10-20H2,3-8H3,(H,34,35);1H2/t22-,23+,24-,25+,26+,29-,30+,31+,32-,33-;/m0./s1
InChI key JMELBGCTIDKOPM-RQBNYOBGSA-N
Quality Level 100 
SMILES string O.CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@](O)(CC=C)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Application: RG-239, a betulinic acid derivative and TGR5/Gpbar-1 agonist, is used to study the role of bile acid activated TGR5 in intestinal motility, inflammation, energy production, glucose homeostasis, glycemic control, obesity and liver steatosis.
Biochem/physiol Actions: RG-239 is a TGR5 agonist
Biochem/physiol Actions: Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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