Ro 41-0960
SIGMA/R108 - solid
Synonym: 2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
CAS Number: 125628-97-9
Empirical Formula (Hill Notation): C13H8FNO5
Molecular Weight: 277.20
MDL Number: MFCD00078597
Linear Formula: C13H8FNO5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: R108-100MG
| color | yellow |
| form | solid |
| InChI | 1S/C13H8FNO5/c14-9-4-2-1- |
| InChI key | RQPAUNZYTYHKHA-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1cc(cc(c1O)[N+]([O-])=O |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclode |
| ethanol: soluble | |
| H2O: slightly soluble <0.7 mg/mL | |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Application: | Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism. |
| Biochem/physiol Actions: | Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids. |
| Disclaimer: | Store tightly sealed at 4 °C, protected from exposure to light. |
| Features and Benefits: | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 25, 100 mg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |