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Raloxifene hydrochloride

SIGMA/R1402 - solid

Synonym: Keoxifene hydrochloride; LY 156758; [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

CAS Number: 82640-04-8
Empirical Formula (Hill Notation): C28H27NO4S · HCl
Molecular Weight: 510.04
MDL Number: MFCD01938233
Linear Formula: C28H27NO4S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R1402-500MG 500 mg
 $594.00
1/EA		 Add To Favorites
45-R1402-1G 1 g
 $1080.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: R1402-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: R1402-500MG

 

color light yellow
form solid
InChI 1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
InChI key BKXVVCILCIUCLG-UHFFFAOYSA-N
originator Eli Lilly
Quality Level 100 
SMILES string Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4
solubility DMSO: soluble 28 mg/mL
  H2O: insoluble
Application: Raloxifene hydrochloride has been used:
• as a competitive inhibitors for estrogen receptor α in breast cancer cells
• as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats
• to test effect on viability of esophageal adenocarcinoma cells
Biochem/physiol Actions: Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
Biochem/physiol Actions: Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen. Raloxifene also interacts with estrogen receptors and plasma proteins.
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1 g in poly bottle
Packaging: 500 mg in poly bottle
UNSPSC 51111800

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