Ramoplanin

SIGMA/R1781

Synonym: A 16686; Antibiotic A 16686

CAS Number: 76168-82-6
MDL Number: MFCD01775776
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-R1781-250MG	250 mg	$516.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
assay	≥75% (as ramoplanin A₂)
form	powder
InChI	1S/C106H170ClN21O30/c1-8-9-10-11-15-22-80(140)114-75(50-78(110)138)96(147)118-76(51-79(111)139)97(148)124-86(60-25-36-66(133)37-26-60)102(153)117-72(21-17-46-109)92(143)120-83(56(6)130)100(151)126-89(63-31-42-69(136)43-32-63)105(156)127-88(62-29-40-68(135)41-30-62)104(155)121-82(55(5)129)99(150)119-74(48-58-18-13-12-14-19-58)95(146)116-71(20-16-45-108)93(144)123-87(61-27-38-67(134)39-28-61)103(154)122-84(57(7)131)101(152)125-85(59-23-34-65(132)35-24-59)98(149)112-52-81(141)115-73(47-53(2)3)94(145)113-54(4)91(142)128-90(106(157)158)64-33-44-77(137)70(107)49-64/h10-15,18-19,22,53-57,59-77,82-90,129-137H,8-9,16-17,20-21,23-52,108-109H2,1-7H3,(H2,110,138)(H2,111,139)(H,112,149)(H,113,145)(H,114,140)(H,115,141)(H,116,146)(H,117,153)(H,118,147)(H,119,150)(H,120,143)(H,121,155)(H,122,154)(H,123,144)(H,124,148)(H,125,152)(H,126,151)(H,127,156)(H,128,142)(H,157,158)/b11-10-,22-15-/t54-,55+,56+,57+,59?,60?,61?,62?,63?,64?,65?,66?,67?,68?,69?,70?,71-,72-,73+,74+,75+,76?,77?,82+,83-,84+,85?,86-,87?,88-,89-,90?/m1/s1
InChI key	FSBZBQUUCNYWOK-YIOPJBSBSA-N
mode of action	cell wall synthesis \| interferes
Quality Level	200
shipped in	dry ice
SMILES string	ClC1C(CCC(C1)C(NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)C(NC(=O)[C@@H](NC(=O)C(NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)C=C/C=CCCC)CC(=O)N)CC(=O)N)C7CCC(CC7)O)CCCN)[C@@H](O
solubility	H₂O: soluble 10 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	Ramoplatin is an antimicrobial which is effective against Gram-positive bacteria, including vancomycin-resistant enterococci. It acts by inhibiting bacterial cell wall synthesis, although its mechanism of action is different from that of glycopeptide-based synthesis inhibitors.
General description:	Chemical structure: glycopeptide
General description:	Ramoplanin is a glycolipodepsipeptide antibiotic produced by Actinoplanes sp. It is a complex of structurally related molcules, with ramoplanin A₂ as the primary component. It is used for in vitro susceptibility testing and to study antibiotic-resistant enterococci.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	250 mg in glass bottle

Symbol	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	nwg
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥75% (as ramoplanin A₂)
Storage Temp.	−20°C
UNSPSC	51102829

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