RS 102895 hydrochloride
SIGMA/R1903 - ≥98% (HPLC), powder
Synonym: 1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
Empirical Formula (Hill Notation): C21H21F3N2O2 · HCl
Molecular Weight: 426.86
MDL Number: MFCD08703093
Linear Formula: C21H21F3N2O2 · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C21H21F3N2O2.ClH/c22-2 |
| InChI key | KRRISOFSWVKYBF-UHFFFAOYSA |
| mol wt | 426.86 g/mol |
| packaging | pkg of 5 mg |
| Quality Level | 100  |
| SMILES string | Cl.FC(F)(F)c1ccc(CCN2CCC3 |
| solubility | DMSO: >10 mg/mL |
| storage condition | desiccated |
| storage temp. | 20-25°C |
| Application: | RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia. |
| Biochem/physiol Actions: | RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses. |
| General description: | RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class. |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 20-25°C |
| UNSPSC | 12352202 |