Reversine
SIGMA/R3904 - ≥98% (HPLC), solid
Synonym: 2-
CAS Number: 656820-32-5
Empirical Formula (Hill Notation): C21H27N7O
Molecular Weight: 393.49
MDL Number: MFCD07784513
Linear Formula: C21H27N7O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| InChI | 1S/C21H27N7O/c1-2-4-15(5- |
| InChI key | ZFLJHSQHILSNCM-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | C1CCC(CC1)Nc2nc(Nc3ccc(cc |
| solubility | DMSO: soluble 7 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
| Application: | Reversine has been used as a monopolar spindle 1 (Mps1) kinase inhibitor or mitotic spindle assembly checkpoint (SAC) inhibitor: • to study the need of mitotic arrest for combretastatin A4 (CA4)-mediated cytotoxicity • to study the contribution of SAC activation to epstein-barr virus (EBV) replication • to induce chromosome mis-segregation |
| Biochem/physiol Actions: | Reversine is an A3 adenosine receptor antagonist, Aurora kinase inhibitor, and Mps1 kinase inhibitor. |
| Biochem/physiol Actions: | Reversine was first described as a synthetic substituted purine with activity as a dedifferentiation agent; it was shown to induces differentiated lineage-committed cells to become multipotent mesenchymal stem cells (MSCs). Reversine has also been show to have activity as a potent, selective human A3 adenosine receptor antagonist (Ki value of 0.66 μM), as an ATP-competitive Aurora kinase inhibitor, and as a Mps1 kinase inhibitor. Additionally, studies have shown reversine to be an anti-cancer agent, inhibiting growth and inducing cell death in various cancer cell types. |
| Packaging: | 1, 5 mg in glass bottle |
| Preparation Note: | According to other sources, stock solutions of Reversine in DMSO are stable refrigerated for short term only. For long term storage aliquotes should be stable at -20°C for up to 2 years. Solution storage at ambient temperature is not recommended. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |