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Rebamipide hydrate

SIGMA/R5655 - ≥98% (HPLC), powder

Synonym: α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate; Mucosta hydrate; OPC 12759 hydrate; Proamipide hydrate

CAS Number: 90098-04-7 (anhydrous)
Empirical Formula (Hill Notation): C19H15ClN2O4 · xH2O
Molecular Weight: 370.79 (anhydrous basis)
MDL Number: MFCD11114396
Linear Formula: C19H15ClN2O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R5655-5MG 5 mg
 $91.20
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45-R5655-25MG 25 mg
 $366.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C19H15ClN2O4.H2O/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15;/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26);1H2
InChI key WQRHVBKNEDPECA-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.OC(=O)C(CC1=CC(=O)Nc2ccccc12)NC(=O)c3ccc(Cl)cc3
solubility DMSO: >5 mg/mL
Biochem/physiol Actions: Rebamipide hydrate is an anti-ulcer agent, an antioxidant, a gastrointestinal agent, and a gastric cytoprotectant.
Biochem/physiol Actions: Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Behçet′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.
Biochem/physiol Actions: Rebamipide helps to reduce intestinal injury, stimulated by radiation.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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