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Ranolazine dihydrochloride

SIGMA/R6152 - ≥98% (HPLC), powder

Synonym: (±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride; N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

CAS Number: 95635-56-6
Empirical Formula (Hill Notation): C24H33N3O4 · 2HCl
Molecular Weight: 500.46
MDL Number: MFCD03788770
Linear Formula: C24H33N3O4 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R6152-100MG 100 mg
 $296.00
1/EA		 Add To Favorites
45-R6152-500MG 500 mg
 $1010.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
InChI key RJNSNFZXAZXOFX-UHFFFAOYSA-N
mp 222-229.5 °C (lit.)
originator Gilead
Quality Level 100 
SMILES string Cl.Cl.COc1ccccc1OCC(O)CN2CCN(CC2)CC(=O)Nc3c(C)cccc3C
solubility H2O: soluble ≥10 mg/mL
storage condition desiccated
Application: Ranolazine dihydrochloride has been used:
• as a low Torsades-de-pointes (TdP) risk drug to study its effects on QTc prolongation, electrocardiographic (PR and QRS) intervals in dog cardiovascular model
• as a partial fatty acid oxidation (FAO) inhibitor to study its effects on glioblastoma cells
• as a late sodium(Na+)-current (INaL) inhibitor to study its effects on atrial tachycardia in rabbit heart
Biochem/physiol Actions: pFOX (partial fatty acid oxidation) inhibitor, a new class of anti-anginal drugs, which inhibit fatty acid beta-oxidation and activates pyruvate dehydrogenase, thereby diverting the heart′s energy source from lipids to glucose, which requires less oxygen and helps maintain myocardiac function at times of ischemia
Biochem/physiol Actions: Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.
Features and Benefits: This compound was developed by Gilead . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 100, 500 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 222-229.5 °C (lit.)
UNSPSC 12352200

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