Anti-phospho-Retinoblastoma (pSer807,811) antibody produced in rabbit
SIGMA/R6400 - affinity isolated antibody, buffered aqueous glycerol solution
MDL Number: MFCD02097167
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer807/pSer811) |
| technique(s) | western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation |
| UniProt accession no. | P06400  |
| Application: | Anti-phospho-Retinoblasto |
| Biochem/physiol Actions: | RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation. |
| Biochem/physiol Actions: | Recognizes phosphorylated Rb (Ser807/Ser811) and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene. |
| Immunogen: | synthetic peptide corresponding to residues around phosphoserine 807/811 of the human retinoblastoma tumor suppressor protein (Rb), conjugated to KLH. |
| Physical form: | Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol. |
| Preparation Note: | Purified using protein A and peptide affinity chromatography. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |