Rolipram
SIGMA/R6520 - solid, ≥98% (HPLC)
Synonym: 4-
CAS Number: 61413-54-5
Empirical Formula (Hill Notation): C16H21NO3
Molecular Weight: 275.34
EC Number: 262-771-1
MDL Number: MFCD00270906
Linear Formula: C16H21NO3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: R6520-100MG
| assay | ≥98% (HPLC) |
| biological source | synthetic (organic) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C16H21NO3/c1-19-14-7-6 |
| InChI key | HJORMJIFDVBMOB-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(cc1OC2CCCC2)C3CNC |
| solubility | DMSO: 7.3 mg/mL |
| ethanol: 7 mg/mL | |
| H2O: 0.2 mg/mL |
| Application: | Rolipram has been used: • to investigate its effects on testicular torsion–detorsion injury(36) • to block the effects of phosphodiesterase-4 (PDE4)(37) • as a component in chemically induced long-term potentiation (cLTP) induction media(38) |
| Biochem/physiol Actions: | Selective cAMP-specific phosphodiesterase (PDE4) inhibitor. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 25, 100 mg in poly bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 41106305 |