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Ro 25-6981 hydrochloride hydrate

SIGMA/R7150 - ≥98% (HPLC), powder

Synonym: (αR)-(4-Hydroxyphenyl)-(βS)-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate

CAS Number: 919289-58-0 (anhydrous)
Empirical Formula (Hill Notation): C22H29NO2 · HCl · xH2O
Molecular Weight: 375.93 (anhydrous basis)
Linear Formula: C22H29NO2 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R7150-5MG 5 mg
 $197.00
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45-R7150-25MG 25 mg
 $676.00
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1
InChI key FEINQVNMUYISNW-HVDCVHHPSA-N
originator Roche
Quality Level 100 
SMILES string O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
solubility DMSO: >20 mg/mL
storage condition desiccated
Application: Ro 25-6981 hydrochloride hydrate has been used:
• as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
• as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
• to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus
Biochem/physiol Actions: Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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