Synonym: (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride; 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride; Rb/Raf-1 disruptor 251 hydrochloride; S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride
CAS Number: 72214-67-6
Empirical Formula (Hill Notation): C8H8Cl2N2S· HCl
Molecular Weight: 271.59
MDL Number: MFCD00035047
Linear Formula: C8H8Cl2N2S· HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| InChI key |
COMNQRICZGJVLE-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Cl.NC(=N)SCc1ccc(Cl)cc1Cl |
| solubility |
DMSO: >10 mg/mL |
| |
H2O: >2 mg/mL |
| storage condition |
desiccated |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. |
| Biochem/physiol Actions: |
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard Codes |
Xn |
| Risk Statements |
22-36/37/38 |
| Safety Statements |
26 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
