RG108

SIGMA/R8279 - ≥98% (HPLC), powder

Synonym: N-Phthalyl-L-tryptophan

CAS Number: 48208-26-0
Empirical Formula (Hill Notation): C₁₉H₁₄N₂O₄
Molecular Weight: 334.33
Linear Formula: C₁₉H₁₄N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-R8279-10MG	10 mg	$314.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChI key	LMAZUAXDZRILNJ-INIZCTEOSA-N
optical activity	[α]/D -250 to -310°, c = 0.5 in methanol
Quality Level	100
SMILES string	OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
solubility	DMSO: >10 mg/mL
storage temp.	−20°C

Application:	RG108 has been used: • in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC) • as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells • as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)
Biochem/physiol Actions:	RG108 is a DNA methyltransferase (DMNT) inhibitor.
Biochem/physiol Actions:	RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.
Biochem/physiol Actions:	RG108 is less cytotoxic compared to azacytidine (5-Aza-dCR). It mediates radiosensitivity in esophageal cancer cells (EC). RG108 is a potent epigenetic modulator and a demethylating agent. It elicits non-cytotoxic functionality and may be useful in stem cell therapies based on human bone marrow-derived mesenchymal stem cells (hBMSCs). It interacts with DNA methyltransferase 1 at the catalytic domain region.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.
Packaging:	10 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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