RO-52 (SSA) human
SIGMA/R8526 - recombinant, expressed in E. coli, liquid
Synonym: Anti-RO-52 antibody
MDL Number: MFCD03458409
Product Type: Chemical
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| biological source | human |
| form | liquid |
| mol wt | 52 kDa by SDS-PAGE |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage temp. | −70°C |
| technique(s) | ELISA: suitable |
| UniProt accession no. | P19474  |
| Application: | RO-52 (SSA) human has been used: • as a component of the autoantigen array • to immobilise protein on the self-assembly monolayer • in enzyme-linked immunosorbent assays (ELISAs) |
| Biochem/physiol Actions: | RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE. |
| Biochem/physiol Actions: | Used for the detection and quantification of antibodies to RNPs in rheumatic diseases. |
| General description: | Research area: Cell Signaling RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. |
| Physical form: | solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |