Synonym: (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); ICI 59118; ICRF 159; NSC 129943; Razoxin; Tepirone; Troxozone
CAS Number: 21416-67-1
Empirical Formula (Hill Notation): C11H16N4O4
Molecular Weight: 268.27
EC Number: 244-379-2
MDL Number: MFCD00430424
Linear Formula: C11H16N4O4
Product Type: Chemical
| assay |
>98% (HPLC) |
| form |
solid |
| InChI |
1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19) |
| InChI key |
BMKDZUISNHGIBY-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
| solubility |
DMSO: 40 mg/mL |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells. |
| Biochem/physiol Actions: |
Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
>98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
