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Raltitrexed

SIGMA/R9156 - ≥98% (HPLC), solid

Synonym: L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl); ICI-D-1694; ZD-1694

CAS Number: 112887-68-0
Empirical Formula (Hill Notation): C21H22N4O6S
Molecular Weight: 458.49
Linear Formula: C21H22N4O6S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R9156-10MG 10 mg
 $174.00
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45-R9156-50MG 50 mg
 $692.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: R9156-50MG

 

assay ≥98% (HPLC)
color off-white to light yellow
form solid
originator AstraZeneca
Quality Level 100 
SMILES string O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2
solubility DMSO: ≥40 mg/mL
  H2O: ≥10 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives.
Biochem/physiol Actions: Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10 mg in glass bottle
Packaging: 50 mg in poly bottle
Symbol GHS06GHS08  GHS06,GHS08
Signal word Danger
Hazard statements H300 - H360
Precautionary statements P201 - P301 + P310 + P330
Hazard Codes T
Risk Statements 61-25
Safety Statements 53-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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