Monoclonal Anti-RANTES antibody produced in rat
SIGMA/R9400 - clone 53405.111, purified immunoglobulin, lyophilized powder
Synonym: Anti-D17S136E; Anti-RANTES; Anti-SCYA5; Anti-SIS-delta; Anti-SISd; Anti-TCP228; Anti-eoCP
MDL Number: MFCD01635727
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rat |
| clone | 53405.111, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG2a |
| purified by | using protein G |
| Quality Level | 100  |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: 8-25 μg/mL using mouse splenocytes |
| neutralization: suitable | |
| UniProt accession no. | P30882  |
| Biochem/physiol Actions: | RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | purified, E. coli-derived, recombinant mouse RANTES. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |