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Phospho-Stat1 (pSer727) and pan-Stat1 ELISA Kit

SIGMA/RAB0441 - for detection of phospho-stat1 (pSer727) and pan-stat1 in human or mouse cell and tissue lysates

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-RAB0441-1KT 1 kit
 $839.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

shipped in wet ice
species reactivity mouse, human
storage temp. −20°C
technique(s) capture ELISA: suitable
  ELISA: suitable
Application: For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure  (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions: Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.
General description: The Phospho-Stat1 (pSer727) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Immunogen: Stat1 (pTyr727) synthetic phosphopeptide, Recombinant Human STAT1
Symbol GHS05GHS07  GHS05,GHS07
Signal word Warning
Hazard statements H290 - H335
Hazard Codes Xi
Risk Statements 37
RIDADR UN 3264 8 / PGIII
Storage Temp. −20°C
UNSPSC 41116158

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