Trizma® hydrochloride
SIGMA/RDD009 - anhydrous, free-flowing, Redi-Dri™, ≥99.0%
Synonym: TRIS HCl; TRIS hydrochloride; Tris(hydroxymethyl)
CAS Number: 1185-53-1
Empirical Formula (Hill Notation): C4H11NO3 · HCl
Molecular Weight: 157.60
EC Number: 214-684-5
MDL Number: MFCD00012590
Linear Formula: NH2C(CH2OH)3 · HCl
Product Type: Chemical
| absorption | ≤0.05 at 290 nm at 40% |
| assay | ≥99.0% |
| color | white |
| form | powder |
| grade | anhydrous |
| impurities | ≤0.5% water (Karl Fischer) |
| InChI | 1S/C4H11NO3.ClH/c5-4(1-6, |
| InChI key | QKNYBSVHEMOAJP-UHFFFAOYSA |
| mp | 150-152 °C |
| pKa (25 °C) | 8.1 |
| product line | Redi-Dri™ |
| quality | free-flowing |
| Quality Level | 100 ![]() |
| SMILES string | Cl.NC(CO)(CO)CO |
| solubility | H2O: soluble, clear, colorless |
| useful pH range | 7.0-9.0 |
| Legal Information: | Redi-Dri is a trademark of Sigma-Aldrich Co. LLC |
| Legal Information: | Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution. For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode. |
| Packaging: | 1, 2.5 kg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% |
| mp | 150-152 °C |
| UNSPSC | 12161700 |

