BIS-TRIS hydrochloride
SIGMA/RES1164B-A7
Synonym: BIS-TRIS hydrochloride; 2,2-
CAS Number: 124763-51-5
Empirical Formula (Hill Notation): C8H19NO5 · HCl
Molecular Weight: 245.70
MDL Number: MFCD00171252
Linear Formula: C8H19NO5 · HCl
Product Type: Chemical
| biological source | synthetic |
| foreign activity | Cytotoxicity, DNase, NICKase, RNase, and Protease; tested |
| form | powder |
| impurities | Endotoxin and microbial; tested |
| InChI | 1S/C8H19NO5.ClH/c10-3-1-9 |
| InChI key | VEYRVLHAMHQVTC-UHFFFAOYSA |
| pKa | 6.5 |
| Quality Level | 400 ![]() |
| SMILES string | Cl.OCCN(CCO)C(CO)(CO)CO |
| suitability | suitable for manufacturing use |
| technique(s) | cell culture | mammalian: suitable |
| useful pH range | 5.8-7.2 |
| Application: | Bis Tris HCl is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36, which makes it a good candidate for biological-based formulations. Bis Tris HCl can be used in a wide variety of biological applications including culture media, electrophoresis separations and diagnostic reagent formulations. |
| General description: | Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program. M-Clarity Program ![]() Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step. Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs. |
| Legal Information: | SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | Product is available in the following package sizes: RES1164B-A701X: 100 gm container RES1164B-A702X: 1 kg container RES1164B-A704X: 10 kg container |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12161705 |

