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(±)-Sotalol hydrochloride

SIGMA/S0278 - ≥98% (TLC), powder

Synonym: N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

CAS Number: 959-24-0
Empirical Formula (Hill Notation): C12H20N2O3S · HCl
Molecular Weight: 308.82
EC Number: 213-496-0
MDL Number: MFCD00242937
Linear Formula: C12H20N2O3S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S0278-25MG 25 mg
 $112.00
1/EA		 Add To Favorites
45-S0278-100MG 100 mg
 $361.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S0278-100MG

 

assay ≥98% (TLC)
color white to off-white
form powder
InChI 1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChI key VIDRYROWYFWGSY-UHFFFAOYSA-N
originator Bayer
Quality Level 200 
SMILES string Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
solubility H2O: 20 mg/mL
Application: (±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.
Biochem/physiol Actions: Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Biochem/physiol Actions: Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 100 mg in glass bottle
Packaging: 25 mg in poly bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
UNSPSC 12352200

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