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Silymarin

SIGMA/S0292 - flavonolignans

Synonym: flavolignans

CAS Number: 65666-07-1
MDL Number: MFCD01776359
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S0292-10G 10 g
 $62.20
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45-S0292-50G 50 g
 $185.00
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application(s) microbiology
biological source plant (Silybum marianum)
form powder
InChI 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChI key SEBFKMXJBCUCAI-UHFFFAOYSA-N
Quality Level 200 
SMILES string O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
storage temp. −20°C
technique(s) toxicology assay: suitable
Application: Silymarin has been used to study:
• its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
• its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
• its effect on liver toxication induced by Fumonisin B1 in mice

Biochem/physiol Actions: Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.
Biochem/physiol Actions: Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.
Biochem/physiol Actions: Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.
General description: Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.
Other Notes: Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352202

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